Mitragyna speciosa is an evergreen tree that can grow to a height of 25 m (82 ft). Its trunk may grow to a 0.9 m (3 ft) diameter.[20] The trunk is generally straight, and the outer bark is smooth and grey.[20] The leaves are dark green and glossy[7] and can grow to over 14–20 cm (5.5–7.9 in) long and 7–12 cm (2.8–4.7 in) wide when fully open, are ovate-acuminate in shape, and opposite in growth pattern, with 12–17 pairs of veins.[20] The flowers grow in clusters of three at the ends of the branches. The calyx-tube is 2 mm (0.08 in) long and has five lobes; the corolla-tube is 2.5–3 millimetres (0.098–0.12 in) long.[20]

Mitragyna speciosa is indigenous to Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea.[3] It was first formally described by the Dutch colonial botanist Pieter Korthals in 1839, who named it Stephegyne speciosa; it was renamed and reclassified several times before George Darby Haviland provided the final name and classification in 1859.[20]:59

Mitragyna speciosa (ketum, kratom or kratum, Thai: กระท่อม) is a tropical deciduous and evergreen tree in the coffee family (Rubiaceae) with a long history of medicinal use in Southeast Asia, particularly in Thailand or Malaysia.

Kratom

In low dosages of a few grams of leaf, kratom functions primarily as a stimulant, with effects similar to caffeine without the marked jitteriness of drinking several cups of coffee. In higher dosages, kratom functions as a neurological opiate, triggering the mu opiate receptors in the brain, even though kratom is chemically different from the opium derived medications such as codeine, morphine, hydrocodone, and oxycodone.

Kratom

Until 2002, the alkaloid mitragynine was believed to be the primary active ingredient in kratom. Out of all the alkaloids in kratom, there is more mitragynine than any other alkaloid. In the 1970’s, the predecessor of the pharmaceutical giant GSK did research into the medicinal potential of mitragyna speciosa. They did a scientific study comparing the effects of pure mitragynine to crude extract of kratom leaf and found that mitragynine by itself was not an effective analgesic medicine. They subsequently decided that there was no medical use for kratom.

kratom-leafs 2

In 2002, the true active alkaloid in kratom, 7-hydroxymitragynine, was discovered by a group of Japanese researchers. These researchers have filed a patent for all possible medical derivatives of mitragynine and over the next few decades will likely bring kratom derivatives to market as patented pharmaceutical drugs.

Kratom